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Normally zebrafish, which carry the same p53 gene as humans, can survive low doses of radiation, which causes damage to the DNA, because the gene steps in to repair that damage. But no such repair took place in zebrafish without the isoform switch, and they died after radiation exposure. The researchers said this proved that the switch played a crucial role in enabling p53 to do its repair work.
A Vietnamese man is in a stable condition in hospital after doctors removed a giant tumour which weighed far more than the rest of his body.
2012-01-06
Vietnam tumour surgery incredible