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As thousands prepare for the London Marathon, the world's best face perhaps the most awe-inspiring barrier in sporting endeavour - the sub two-hour marathon.


 Marathon running endurance record London
Endorphins ("endogenous morphine") are endogenous opioid peptides that function as neurotransmitters. They are produced by the pituitary gland and the hypothalamus in vertebrates during exercise, excitement, pain, consumption of spicy food, love and orgasm, and they resemble the opiates in their abilities to produce analgesia and a feeling of well-being.
 endorphin neuroscience brain exercise orgasm running hypothalamus happiness endurance pregnancy achievement challenge satisfaction Wikipedia
US swimmer Diana Nyad has been forced to abandon her attempt to be the first person to swim from Cuba to Florida without the protection of a shark cage. Ms Nyad, 61, stopped 29 hours into an expected 60-hour swim.


 swimming long-distance Cuba USA Cold War endurance